LineageResolved Enhancer and Promoter Usage during a Time Course of
LineageResolved Enhancer and Promoter Usage during a Time Course of Embryogenesis Reddington JP 1 Garfield DA 1 Sigalova OM 1 Karabacak Calviello A 2 MarcoFerreres R 1 Enhancers are essential drivers of cell states yet the relationship between accessibility regulatory activity and in vivo lineage commitment during embryogenesis
Enhancerpromoter interactions become more instructive in the
Resource LineageResolved Enhancer and Promoter Usage during a Time Course of Embryogenesis James P Reddington13 David A Garfield13 Olga M Sigalova13 Aslihan Karabacak Calviello23 Raquel MarcoFerreres 1Charles Girardot Rebecca R Viales Jacob F Degner1 Uwe Ohler2 and Eileen EM Furlong1 4 1European Molecular Biology Laboratory EMBL Genome Biology Unit 69117
LineageResolved Enhancer and Promoter Usage during a Time Course of
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Request PDF LineageResolved Enhancer and Promoter Usage during a Time Course of Embryogenesis Enhancers are essential drivers of cell states yet the relationship between accessibility
In some cases the enhancer only comes into proximity or interacts with the genes promoter in the appropriate cell type and developmental stage where the gene is expressed 1 Reddington JP et al Lineageresolved enhancer and promoter usage during a time course of embryogenesis Dev Cell 2020 55648664 doi
Lineage Resolved Enhancer And Promoter Usage Cell Press
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LineageResolved Enhancer and Promoter Usage during a Time Course of
Reddington et al generate tissuespecific maps of chromatin accessibility across a time course of Drosophila embryogenesis They dissect the relationship between enhancerpromoter accessibility and activity and demonstrate the power of this resource to annotate singlecell data and identify regulatory elements predictive sequence features and many regulators in each lineages development
Enhancers are essential drivers of cell states yet the relationship between accessibility regulatory activity and in vivo lineage commitment during embryogenesis remains poorly understood Here we measure chromatin accessibility in isolated neural and mesodermal lineages across a time course of Drosophila embryogenesis Promoters including tissuespecific genes are often constitutively
Lineage resolved enhancer and promoter usage during a timecourse of embryogenesis Reddington JP Garfield DA Sigalova O Calviello AK MarcoFerreres R Girardot C Viales RR Degner JF Ohler U Furlong EEM These authors contributed equally to this work Developmental Cell 2020 Dec doi 101016jdevcel202010009 Developmental
Reddington et al Lineage resolved enhancer and promoter usage during a timecourse of embryogenesis 3 Figure S3 Related to Figure 1 Comparison of this DHS atlas to sciATAC data and characterised enhancers A Peak calling subsampling analysis showing peak calling is close to saturation the
Lineage Resolved Enhancer And Promoter Usage Cell Press
Item Type Article Title Lineageresolved enhancer and promoter usage during a time course of embryogenesis Creators Name Reddington JP and Garfield DA and
An enhancer prediction system in Tribolium based on time and tissuespecific ATACseq and an enhancer live reporter system based on MS2 tagging is established and data is found consistent with a model in which the timing of gene expression during embryonic pattern formation is mediated by a balancing act between enhancers that induce rapid changes in gene expressions and enhancer that
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Lineageresolved enhancer and promoter usage during a time course of